Archives2018Vol. 58, No. 1pp. 5-14

Article

DNA Damage-Independent Cell Cycle Arrest in the Yeast Saccharomyces cerevisiae

Koltovaya N.A.1

1 Joint Institute for Nuclear Research, Dubna, Russia

Abstract

It is known that ionizing radiation induces DNA damage, which activates genetically determined cell cycle arrest (checkpoint), damage repair, or cell death. Besides, on the one part, other cell structures are damaged by radiation, too; on the other part, the disorder of cell structure biogenesis can cause cell cycle arrest. It can be suggested that radiation induces cell cycle arrest determined by the damage of the cell structures other than DNA — with the possible involvement of the same checkpoint mechanism as in the case of DNA damage, excluding sensors and mediators. Control of the DNA integrity in general is already known; less studied cell morphology control is examined here. Special attention is given to the participation of the central kinase of cell division regulation CDK1/CDC28 in the morphological checkpoint control.

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