Archives → 2018 → Vol. 58, No. 5 → pp. 490-497
Article
Peculiarities of Immune Status in People Exposed to Chronic Irradiation and Having High Levels of Chromosomal Aberrations at Later Time Points
Akleyev A.A.1,2, Vozilova A.V.1, Dolgushin I.I.2
1Urals Research Center for Radiation Medicine of the FMBA of Russia, Chelyabinsk, Russia. 2 Southern-Urals State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia
Abstract
Long after chronic radiation exposure mainly of red bone marrow (mean exposure dose was 0.98 ± 0.05 Gy, individual dose range was 0.08–2.14 Gy) minor changes in the T-cell immunity such as a decrease in the relative number of CD3+-lymphocytes as well as the decreased absolute number of CD4+-cells, which did not depend on the maximum dose-rate and absorbed dose to red bone marrow and soft tissues, were observed in peripheral blood lymphocytes of the individuals with elevated levels of chromosomal aberrations (mainly dicentrics and translocations). The concomitant increase in the relative number of CD19+-lymphocytes, which was mainly determined by the dose-rate and absorbed dose to soft tissues, indicated a shift of immunological balance in the direction of the humoral immune response.
Keywords
chronic irradiation, red bone marrow, chromosomal aberrations, immune status
Current Issue
FAQs
The length of a manuscript should be justified by its content.
Agreement as pdf file signed by all co-authors must be submitted by e-mail together with all materials of the article. Original hard copies of the agreement (two copies) must be sent by post to the address of the Editorial Board.