Archives2018Vol. 58, No. 5pp. 490-497

Article

Peculiarities of Immune Status in People Exposed to Chronic Irradiation and Having High Levels of Chromosomal Aberrations at Later Time Points

Akleyev A.A.1,2, Vozilova A.V.1, Dolgushin I.I.2

1Urals Research Center for Radiation Medicine of the FMBA of Russia, Chelyabinsk, Russia. 2 Southern-Urals State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia

Abstract

Long after chronic radiation exposure mainly of red bone marrow (mean exposure dose was 0.98 ± 0.05 Gy, individual dose range was 0.08–2.14 Gy) minor changes in the T-cell immunity such as a decrease in the relative number of CD3+-lymphocytes as well as the decreased absolute number of CD4+-cells, which did not depend on the maximum dose-rate and absorbed dose to red bone marrow and soft tissues, were observed in peripheral blood lymphocytes of the individuals with elevated levels of chromosomal aberrations (mainly dicentrics and translocations). The concomitant increase in the relative number of CD19+-lymphocytes, which was mainly determined by the dose-rate and absorbed dose to soft tissues, indicated a shift of immunological balance in the direction of the humoral immune response.

Keywords

chronic irradiation, red bone marrow, chromosomal aberrations, immune status

Current Issue

FAQs

What are the maximum and minimum lengths of a manuscript?

The length of a manuscript should be justified by its content.

When should a copyright agreement be submitted?

Agreement as pdf file signed by all co-authors must be submitted by e-mail together with all materials of the article. Original hard copies of the agreement (two copies) must be sent by post to the address of the Editorial Board.

all questions